C-mesenchymal-epithelial transition factor (c-MET) is a transmembrane receptor with autonomic phosphorylation activity encoded by MET. Normal c-MET pathway promotes tissue differentiation and repair, while c-MET dysregulation can result in tumor cell proliferation and metastasis [1]. MET amplification, MET exon 14 skipping mutation and c-MET overexpression are main mechanisms inducing aberrant activation of c-MET pathway in lung cancer. The gene discussed is MET; the disease is lung carcinoma.