This includes lower levels of synaptophysin and other synaptic vesicle proteins [89, 121–124], lower transcript levels of SV2A [137], lower cortical dendritic spine density and other post-synaptic elements, [90, 117, 118, 120] and lower spine plasticity [139], in the context of unaltered neuronal numbers in schizophrenia [115]. The gene discussed is SV2A; the disease is schizophrenia.