Vice versa, given that DHA inhibits Scd1 expression [77], the beneficial impact of DHA supplementation on Treg differentiation, EAE severity, and disease pathology of autoimmune disorders such as MS, systemic lupus erythematosus, and rheumatoid arthritis might depend on changes in SCD1 activity [54, 78]. Here, SCD is linked to systemic lupus erythematosus.