Genes positively correlated with purity showed enrichment in cancer-related pathways and processes such as epithelial-mesenchymal transition (BASP1, COL4A1, THBS2), genes involved in the TNFA signaling via NFKB (SPSB1, SMAD3), and genes upregulated by KRAS activation (CFB, MAFB). The gene discussed is SMAD3; the disease is cancer.