Therefore, we speculate that during the acute phase of AIDP, the CD14 + CD163 + IL1R2 + monocyte cell types, which receive IL1β signals from CD14 + and CD16 + monocytes, may be amplified in peripheral blood and subsequently migrate to peripheral nerves under the action of chemokine pathways, leading to macrophage mediated phagocytosis or peripheral nerve demyelination (Fig. 8). The gene discussed is IL1R2; the disease is Guillain-Barre syndrome, familial.