Haisma et al. fused neutralizing anti-adenovirus fiber scFv Ab (S11) to EGF-mediated adenovirus retargeting to EGF receptor-positive cells.81 A similar strategy to identify potential bi-soluble adapters for targeting cognate tumor receptors has been adopted in HSV-1 modified with P-V528LH adapter fused to an EGFR-specific monoclonal antibody consisting of gD ectodomain binding region of nectin-1, which is found overexpressed in breast and colorectal cancer.82 OV can also be modified to accurately target human epidermal growth factor receptor 2 (HER2). Here, ERBB2 is linked to colorectal cancer.