ERBB2 and neoplasm: An H5CmTERT-Ad expressing secretable trimeric tumor necrosis factor-related apoptosis-inducing ligand (H5CmTERT-Ad/TRAIL) was generated by Oh et al. and exhibited a more potent tumor-killing effect in contrast to a cognate control Ad by inducing strong apoptosis.126 Loya et al. armed FusOn-H3 (i.e., engineered oHSV-2) with apoptosis activators Her2-COL-sFasL to increase the caspase activation (especially caspase-3 and -8) in infected cells and bystander killing effect.127 NDV is one of the OVs that has been studied comprehensively in the mechanism of apoptosis.