Taking advantage of this feature, adenovirus GD55, in which endogenous E1A promoter of E1B 55kD-deleted Ad was replaced by GOLPH2 (a Golgi membrane glycoprotein GP73) promoter, has been demonstrated to have more accurate targeting in HCC.100 In cholangiocarcinoma (CCA), Ads with survivin promoter were designed by Zhu et al., exhibiting higher activity. Here, BIRC5 is linked to cholangiocarcinoma.