PECAM1 and neoplasm: For example, JX-594 can selectively infect endothelial cells in tumor-related vascular systems with increased VEGF and FGF-2 signals.229 G207, an oHSV-1, was found to replicate actively in CD31+ endothelial cells and reduced tumor neovasculature in malignant peripheral nerve sheath tumors (MPNSTs) model.230 Breitbach et al. adopted a three-dimensional (3D) reconstruction of infected tumors, revealing the direct infection and damage to the tumor vasculature by VSV.231 Other OVs were modified to target tumor vasculature or receptors of endothelial cells.