Compared with unloaded CAR T cells, OV-infected CAR-T allowed further in vivo expansion and reactivation of T cells through homologous enhancement and prolonged survival of mice with subcutaneous melanoma and intracranial glioma tumors.300 Another novel idea was that IL-2-armed oncolytic poxvirus stimulates the accumulation of tumor-specific TILs in hypoimmunogenic tumor tissues. This evidence concerns the gene IL2 and neoplasm.