Reovirus can be utilized as an OV to target cancer cells since JAM-A is overexpressed in a series of cancers, including breast cancer,53 non-small cell lung cancer,54 diffuse large B-cell lymphoma,55 and multiple myeloma.56 Upon infection, the outer capsid is acid-dependently cleaved in endosomes and the transcriptionally active core is subsequently released.57 The transcription and translation event for the assembly of progeny virus happen in viral inclusions located in the cytoplasm. The gene discussed is F11R; the disease is cancer.