PAEP and hepatocellular carcinoma: It happens to be the natural receptor of poliovirus, rendering poliovirus the ability to selectively infect tumor cells.76 Reolysin®, a wild-type variant of reovirus (i.e., T3D strain), has been demonstrated to have oncolytic activity across a spectrum of malignancies depending on RAS signaling.77 HSV gD protein binds to herpesvirus entry mediator (HVEM), which has been reported upregulated in melanoma, gastric cancer and hepatocellular carcinoma (HCC).78