Adenoviruses engineered to express tumor TNF-α and IL-2 were delivered in an anti-PD-1-resistant melanoma model, showing a prolonged survival time, an increased CD8+ T-cell infiltration and a reduced proportion of M2 macrophages and MDSCs.184 IFN-γ functions by promoting immune cell migration and propagation toward TME. This evidence concerns the gene CD8A and melanoma.