Notably, the frequency of these tumor-associated neutrophils was heightened with treatment with STEAP1-mBBζ CAR T cells compared to untransduced T cells (54 vs. 34%), diminished in conditions with CBD-IL-12 therapy, but increased upon tumor relapse after combined STEAP1-mBBζ CAR T cell and CBD-IL-12 therapy (19 to 42%). This evidence concerns the gene STEAP1 and neoplasm.