STEAP1 and neoplasm: To broaden the antitumor response, we investigated the systemic administration of CBD-IL-12 in combination with STEAP1-BBζ CAR T cell therapy in a disseminated, syngeneic RM9-hSTEAP1 tumor model in hSTEAP1-KI mice to approximate the immunosuppressive nature of mCRPC based on prior characterization of RM9 as a poorly immunogenic model57,77.