Next, we investigated the effect of cRGD-lipo-LGAL administration on TAK1 phosphorylation and MMP9 expression in TNBC primary tumors: both were significantly reduced in the tumor tissues of the cRGD-lipo-LGAL-treated mice, revealing a positive association between TAK1 phosphorylation and MMP9 expression in tumor tissues (Fig. 8D). The gene discussed is MMP9; the disease is neoplasm.