While due to the high mutation frequency of HCC patients in Asia, in addition to the classic p53-dependent pathway, GRP75 was also shown to play an irreplaceable role in promoting cancer, involving cell cycle regulation, mitochondrial function, stress response, anti-apoptosis, metabolic regulation and other important cell biological behaviors, as well as the regulatory changes of a variety of important transcription factors, kinase/ phosphatase and related downstream key proteins [29]. Here, TP53 is linked to hepatocellular carcinoma.