Here, we compared basal and α-melanocyte-stimulating hormone (α-MSH)-activated signaling between WT hMC4R and published hMC4R constitutively active variants associated with obesity, non-constitutively active hMC4R variants associated with obesity, constitutively active hMC4R variants not associated with obesity, and non-constitutively active hMC4R variants associated with reduced risk of developing obesity (Supplementary Fig. 1 and Supplementary Table 1, see section on supplementary materials given at the end of this article). Here, STAMBP is linked to obesity disorder.