Our data showed that IRF9 (exon 6-7-8) overexpression not only increased IFNA2 and IFNB1 expression in NB cells and CD11b+CD80+ monocytes but also rescued PTBP2-knockingdown-induced inhibition of IFN expression and CD11b+CD80+ monocytes, while CD11b+CD209+ monocytes showed the reverse tendency (Fig. 4H and I). The gene discussed is CD80; the disease is neuroblastoma.