Notably, cellular alternative mRNA splicing pathway process-related proteins, such as splicing factor proline and glutamine rich (SFPQ), matrin 3 (MATR3), PTBP2, non-POU domain containing octamer binding (NONO), eukaryotic translation initiation factor 2B subunit delta (EIF2B4), high mobility group box 3 (HMGB3), protein kinase C beta (PRKCB), raftlin, lipid raft linker 1 (RFTN1), and NRAS proto-oncogene, GTPase (NRAS), were significantly upregulated in patients with FP-NB (Fig. 1A). The gene discussed is PTBP2; the disease is neuroblastoma.