ITGAM and colorectal carcinoma: Moreover, treatment with healthy human-derived plasma exosomes inhibited the proliferation (Fig. 3E and H and S10), migration (Fig. 3F and I), and invasion (Fig. 3G and J) of HCT116 and SW480; however, it had no impact on apoptosis of CRC cells (S11), indicating that exosomes from HC groups with ITGAM high expression failed to support malignancy of CRC cell lines.