Meanwhile, for the prognostic biomarkers to discriminate primary CRC and metastatic CRC, the AUC was 0.9091 (95% CI, 0.7602 to 1) for epithelial growth factor, 0.8727 (95% CI, 0.7177 to 1) for ITGA6, 0.8636 (95% CI, 0.7012 to 1) for ADAM10, and 0.8545 (95% CI, 0.6878 to 1) for ITGB3, respectively. The gene discussed is ITGA6; the disease is colorectal carcinoma.