We also identified proteins that were significantly decreased in CRC groups, including ITGAM, 5'-nucleotidase ecto (NT5E), C-C motif chemokine receptor 2 (CCR2), Thy-1 cell surface antigen (THY1), Integrin alpha L (ITGAL), TIMP metallopeptidase inhibitor 1 (TIMP1), and matrix netallopeptidase 2 (MMP2). The gene discussed is ITGAL; the disease is colorectal carcinoma.