Additionally, we also observed the elevated ratio of ITGA6-ITGB3 subpopulation, decreased ratio of CCR2 subpopulation, and ITGAM-ITGAL-ITGB2 subpopulation in CRC groups, as shown in S12 and S13, which correlated with our findings in Figs. 1 and 2. Here, ITGAL is linked to colorectal carcinoma.