HMGB1 and central nervous system cancer: For example, NDV-induced necroptosis in glioma cells (sensitive to necrostatin-based RIPK1 inhibition) has been found to cause the surface exposure of “eat me” signal calreticulin and the release of high mobility group box 1 (HMGB1) and generate a close correlation with potent anti-glioblastoma immunity driven by antigen-specific CD8+ T cells [69].