To further increase ZHX1 binding to alternative partners and test if that affected glomerular disease severity, Zhx2-deficient, Enpep–/–, or dual Zhx2-deficient Enpep–/– mice were injected with the strain-specific Common Cold cocktail threshold nephritogenic dose X/5 (Figure 8F). This evidence concerns the gene ZHX2 and glomerular disorder.