The main findings of this study were as follows: (1) the incidence of KD among febrile children was low; (2) pyuria, ALT level, CRP level, and eosinophilia were important features in predicting KD; and (3) a machine learning model established with XGBoost had an excellent ability to help physicians identify children with KD among all febrile children. Here, CRP is linked to Increased total eosinophil count.