These cancers have wild-type Tumor Protein p53 (TP53), are genomically stable, and have frequent oncogenic alterations to many cellular signaling pathways such as RAS-Mitogen Activated Protein Kinases (MAPK) and The Phospho Inositide 3-Kinase (PI3K)-AKT Serine/Threonine Kinase. The gene discussed is TP53; the disease is cancer.