TRPA1 and familial pancreatic carcinoma: TRP channels have been shown to play a role in Pancreatic cancer biology (Shi et al. 2022), TRPA1 is expressed in the pancreatic ductal adenocarcinoma cell (PDAC) cell lines Panc-1, MIA Paca-2, and BxPC-3 (Cojocaru et al. 2021), and it is located at the interface between the intracellular and extracellular spaces in the cell membrane, sensing and modifying the tumor microenvironment; this in itself is a driver of the aggressiveness of PDAC (Hofschröer et al. 2020).