In addition, TRPA1 was also detected in CD4+ T-cells infiltrating colon tissue samples from patients with UC and CD (Landini et al. 2022), and TRPA1 is involved in the control of CD4+ T-cell activation and proinflammatory responses in two different T-cell-mediated colitis models (Bertin et al. 2017). This evidence concerns the gene TRPA1 and colitis.