Increased expression of TRPA1 in the bladder wall is associated with the establishment of overactive bladder and lower urinary tract symptoms, TRPA1 activation triggers pain, protective reflexes, and local release of peripheral neurotransmitters and is associated with spontaneous and involuntary bladder contractions in spinal cord injury (Blaha et al. 2019; Wu et al. 2021a). The gene discussed is TRPA1; the disease is overactive bladder.