Studies have also shown that HC-030031 treatment reduces the number and magnitude of nonvoiding contractions (NVCs), and inhibition of TRPA1 can effectively reduce bladder activity; TRPA1 antisense oligonucleotide treatment normalized spontaneous phase activity and reduced CA-induced bladder contractions and NVC numbers in spinal cord injury rats (Andrade et al. 2011). This evidence concerns the gene TRPA1 and spinal cord injury.