TIGIT and Granuloma: For the other phenotypic markers (Fig. 10), there were no significant differences between the 2 groups apart from TIGIT+ CD4+ T cells (P = 0.0647) (Fig. 10B), which trended slightly higher in frequency in SIV/ART/Mtb macaques, and ki-67+ CD8+ T cells, which were significantly more frequent in granulomas from SIV-naive animals (P = 0.0092) (Fig. 10F).