IFNG and tuberculosis: Given their conserved nature and ability to elicit IFN-γ responses within PPD+ protected individuals, Rv1196 and Rv0125 were included in the adjuvanted vaccine M72F, which has been shown to protect against the development of TB disease in subjects with asymptomatic Mtb infections and as a boost to the BCG vaccine in mice and rabbits (9, 53, –, 57).