CD4 and lung adenocarcinoma: Spock2 is a gene encoding a complex secreted proteoglycan, and its high expression in lung adenocarcinoma results in elevated proportions of tumor-infiltrating CD8+ T cells, activated memory CD4+ T cells, Treg cells, M1-like macrophages, activated myeloid dendritic cells, and neutrophils, associated with a good prognosis (71).