IL4 and helminthiasis: Preferring interleukin-4 (IL-4) over IL-17 and interferon-γ (IFN-γ) and containing a more pronounced IL-10 and transforming growth factor-β (TGF-β) component, a strong association has emerged between long-term helminth infection and Treg cell activity (20).Treg cells are considered to be powerful negative regulators of the inflammatory response, and different types of Treg cells may play specific roles in different disease models (21).