This paper focuses on the various cellular pathways of mitophagy in MS, such as the classical PINK1/Parkin pathway, the mitophagy receptor FUNDC1, and the BINP3/NIX pathway, as well as the regulatory mechanisms of mitophagy in MS‐related metabolism‐related illness like obesity, IR, DM, NAFLD, AS, and heart disease. Here, PRKN is linked to metabolic dysfunction-associated steatotic liver disease.