The correlation of T2DM and ischemia‐reperfusion is inextricably linked, and adiponectin was found to attenuate the damage caused by reduced blood flow followed by its restoration, leading to an increase in oxidative stress, inflammation, cell death, and disrupted function of the mitochondria in lung‐injured tissues of T2DM mice by activating SIRT1‐ PINK1 signaling‐mediated mitohagy.46 The gene discussed is SIRT1; the disease is type 2 diabetes mellitus.