This paper focuses on the various cellular pathways of mitophagy in MS, such as the classical PINK1/Parkin pathway, the mitophagy receptor FUNDC1, and the BINP3/NIX pathway, as well as the regulatory mechanisms of mitophagy in MS‐related metabolism‐related illness like obesity, IR, DM, NAFLD, AS, and heart disease. Here, BNIP3L is linked to obesity due to melanocortin 4 receptor deficiency.