This paper focuses on the various cellular pathways of mitophagy in MS, such as the classical PINK1/Parkin pathway, the mitophagy receptor FUNDC1, and the BINP3/NIX pathway, as well as the regulatory mechanisms of mitophagy in MS‐related metabolism‐related illness like obesity, IR, DM, NAFLD, AS, and heart disease. This evidence concerns the gene PRKN and Obesity.