Zhou and colleagues50 showed that the NR4A1/DNA‐PKcs/p53 pathway emerged as a novel molecular circadian mechanism leading to NAFLD, NAFLD by regulating mitophagy related to Bnip3 and Drp1, and also confirmed that melatonin stopped mitochondrial fission by interdicting the NR4A1/DNA‐PKcs/p53 pathway and restored mitophagy, finally improving mitochondrial and hepatic feature in NAFLD patients. The gene discussed is NR4A1; the disease is metabolic dysfunction-associated steatotic liver disease.