A study by Li and colleagues25 demonstrated that the downregulation of Sirtuin 3 (Sirt3) inhibited BINP3/NIX pathway‐mediated mitophagy, and activated Sirt3 further activated the ERK‐CREB‐BNIP3 mitophagy pathway, result in the treatment of NAFLD. This evidence concerns the gene SIRT3 and metabolic dysfunction-associated steatotic liver disease.