Consistent with this notion, UNC5B has been linked to neurodegeneration in the 6-OHDA model of Parkinson’s disease (Jasmin et al., 2021) and UNC5C has been nominated as a risk allele in late-onset AD (Wetzel-Smith et al., 2014; Korvatska et al., 2015; Li et al., 2018). Here, UNC5B is linked to Alzheimer disease.