UNC5C and early-onset autosomal dominant Alzheimer disease: Engagement by netrin ligand is thought to suppress the intrinsic apoptotic potential of the UNC5 death domain (Pradella et al., 2021; Wang et al., 2009), while γ-secretase-mediated cleavage of UNC5C has been linked to neuronal apoptosis in Alzheimer’s disease (AD) (Chen et al., 2021).