For instance, reduced expression of the microtubule binding protein Stathmin 2 due to misregulation of its RNA splicing and/or polyadenylation is strongly linked to axonal growth and regeneration defects in TDP-43-associated ALS (Melamed et al., 2019; Klim et al., 2019). The gene discussed is STMN2; the disease is amyotrophic lateral sclerosis.