SOX17 and non-small cell lung carcinoma: In our prior work, we identified a panel of four epigenetic biomarkers, namely SOX17, CDO1, TAC1, and HOXA7, which were shown to be recurrently methylated in NSCLC and can be readily detected in plasma.[15b] In this study, we aimed to develop a simple multiplexed digital MSP approach that would provide parallelized detection of this panel for use in conjunction with low‐dose CT for improved screening of lung cancer in high‐risk populations.