In our prior work, we identified a panel of four epigenetic biomarkers, namely SOX17, CDO1, TAC1, and HOXA7, which were shown to be recurrently methylated in NSCLC and can be readily detected in plasma.[15b] In this study, we aimed to develop a simple multiplexed digital MSP approach that would provide parallelized detection of this panel for use in conjunction with low‐dose CT for improved screening of lung cancer in high‐risk populations. Here, SOX17 is linked to lung carcinoma.