A multi‐step sequence for CRC tumorigenesis has been proposed where alterations in genes involved in cellular pathways, such as EGFR (ERBB1/HER1), MAPK, PI3K, TGF‐β, and WNT/β‐catenin signaling pathways, occur at different stages of tumor progression.12, 13. This evidence concerns the gene EGFR and colorectal carcinoma.