For non-canonical Wnt signaling these include both autosomal dominant and recessive forms of Robinow syndrome (ROR2, WNT5A, DVL1, DVL3, FZD2, NXN) (Afzal et al., 2000; Lima et al., 2022; Person et al., 2010; van Bokhoven et al., 2000; White et al., 2018), Brachydactyly type B1 (ROR2) (Oldridge et al., 2000; Schwabe et al., 2000), Kleipert syndrome (Amor et al., 2019) and Simpson-Golabi-Behmel syndrome type 1 (GPC4) (Waterson et al., 2010). The gene discussed is ROR2; the disease is brachydactyly type B.