Bioinformatics analysis of the genetic information of GC patients in the TCGA database and the GEO database showed that AKR1B10, MUC5AC, TFF2, GKN1, and PGC expression was significantly different between GC tissue and normal tissue and that AKR1B10 expression was closely related to the polarization state of macrophages. This evidence concerns the gene AKR1B10 and gastric cancer.