Abbreviations: MHO: metabolically-healthy obesity, MUO: metabolically unhealthy obesity, LGA: large-for-gestational-age, AGA: appropriate-for-gestational-age, SGA:  small-for-gestational age, BMI-SDS: body mass index-standard deviation score, GDM: Destational diabetes mellitus, IFG: impaired fasting glucose, NAFLD: Non-alcoholic fatty liver disease, NAFLD: Non-alcoholic fatty liver disease, LDL: low density lipoprotein, LDL: low density lipoprotein, HbA1c: glycated hemoglobin, HOMA-IR: homeostasis model assessment insulin resistant, ALT: alanine transaminase, AST: aspartate aminotransferase. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.