HMGA2 and neoplasm: Figure 1 MiRNAs regulate physiological and pathological processes such as cancer, gastrointestinal diseases, cardiac diseases, diabetes, and liver diseases (Chen et al., 2019b; Huang, Zhang & Chen, 2022). The targeting oncogenes of tumor suppressor let-7 include MYC, KRAS and HMGA2, but it act as a tumor promoter when limiting immune cells in tumor microenvironment (Balzeau et al., 2017; Pobezinsky & Wells, 2018).