These metabolic alterations could thus contribute importantly to the development of neurological symptoms like headache, dizziness, and generalized weakness, which have been frequently observed in COVID-19 patients.45, -47 In our pilot study we investigated whether neurological symptoms, sleep disturbance, and fatigue were related to metabolic changes induced by inflammation and IFN-γ-mediated pathways in patients with acute COVID-19 and at FU. Here, IFNG is linked to COVID-19.