When studying for sex specific differences, men with sleeping problems had significantly higher CRP (16.72 vs 4.10 mg/dL, P = .007) and IL-6 levels (133.8 vs 41.8 ng/L, P = .007) compared to men without them, while women with sleep disturbances had no differences in CRP or IL-6 levels, but higher Kyn/Trp (91.3 vs 44.7, P = .025) than women with undisturbed sleep. This evidence concerns the gene IL6 and sleep disorder.