During acute COVID-19, CRP (16.37 vs 3.5 mg/dL, P = .018) and IL-6 concentrations (130.8 vs 41.6 ng/L, P = .009) were significantly higher and Trp levels (42.2 vs 51.8 μmol/L, P = .046) lower in patients with sleeping difficulties (Figure 3). The gene discussed is IL6; the disease is COVID-19.