By contrast, a reduction in netrin-1 level was observed in patients with prostate and brain cancers.28,29 Netrin-1 suppresses pancreatic cancer through the activation of the UNC5B receptor.30 These results indicate that the role of netrin-1 in cancer is variable, which might be due to its binding to different receptors or different origins of cancer cells. Here, NTN1 is linked to familial pancreatic carcinoma.