NEO1 and acute myeloid leukemia: The functions of netrin-1 are mostly mediated by receptors, including DCC, Unc5 homologs, integrins, and Neo1.31–33 The diversity of binding receptors makes netrin-1 a multifunctional molecule that plays different roles in specific cells depending on the receptors it bind with.20,21,34,35 In this study, we performed RT-PCR and western blotting and found that UNC5B was expressed in AML cells, whereas DCC was absent.