Compared with the control group, mice transplanted with IL-37-MSCs had improved survival and reduced systemic lupus erythematosus symptoms, proinflammatory factors (IL-1β, TNF-α, IL-17 and IL- 6) expression, total and autoantibodies (anti-dsDNA and anti-ANA) in serum and urine as well as T-cell numbers in serum and kidney. Here, IL37 is linked to systemic lupus erythematosus.