Likewise, the significant correlation of high pS383/392-ATG4B protein level with unfavorable overall survival was observed in male CRC patients (p = < 0.001, Fig. 3A), different ages (≤ 60: p = 0.003, > 60: p = 0.003, Fig. 3B), cell differentiation (moderate + poor(II + III): p < 0.001, Fig. 3C), AJCC stages (I + II: p = 0.003, III + IV: p = 0.031, Fig. 3D), T stage T3 + T4 (p < 0.001, Fig. 3E), N stage (N0: p < 0.001; N1 + N: p = 0.042, Fig. 3F) and patients without radiation therapy (p < 0.001, Fig. 3G). The gene discussed is ATG4B; the disease is colorectal carcinoma.