ATG4B and colorectal carcinoma: Similar to outcomes from overall survival, high ATG4B protein levels were associated with unfavorable disease-free survival, particularly in CRC patients with advanced stages, such as cell differentiation moderate + poor II + III: p < 0.001, AJCC stages III + IV: p < 0.001; T stage T3 + T4: p = 0.002; N stage N1 + N2: p < 0.001 and patients who did not receive radiation therapy (p = 0.001) (Fig. 4).