ATG4B and colorectal carcinoma: High ATG4B was significantly linked to unfavorable overall survival in male patients with CRC (male: p < 0.001; female: p = 0.08, Fig. 2A), while it was correlated with poor overall survival in CRC patients with both age ≤ 60 (p = 0.012, Fig. 2B) and > 60 (p = 0.002).