Moreover, high ATG4B protein levels was strongly associated with worse overall survival in CRC patients with poor cellular differentiation (p < 0.001, Fig. 2C) and advanced stages (AJCC stages III + IV: p < 0.001, Fig. 2D; T stages III + IV: p < 0.001, Fig. 2E). The gene discussed is ATG4B; the disease is colorectal carcinoma.