In contrast, multiple Cox regression analyses revealed that high levels of pS383/392-ATG4B had higher risk of mortality in CRC patients with early clinicopathological stages (AJCC stage I + II: AHR = 4.81, p = 0.007; N0 stage: AHR = 5.32, p = 0.001; No radiation therapy: AHR = 3.02, p = 0.001, Table 3). Here, ATG4B is linked to colorectal carcinoma.