PLIN2 and Alzheimer disease: For the validation cohort, subject expression score of the ADRP was also significantly elevated in AD patients compared to NCs (t = 4.573, P < 0.001, Fig. 4C) and had an area under the ROC curve of 0.85 (95% confidence interval 0.73–0.98), showing a sensitivity of 78.26% and a specificity of 78.57% at an optimal cutoff value of 0.9 (Fig. 4D).