SPRED2 and Alzheimer disease: Consistent with these previous results, our comparison of the significant blood DNAm from this study with significant brain DNAm associated with AD pathology in two large recent meta-analyses of postmortem brain tissues [9, 110] shows only a few overlapping DNAm (3 CpGs and 8 DMRs), mapped to PRSSL1, LINGO3, SPRED2, HOXA2, NR2F1, CPT1B, HOXA5, ZFPM1 genes, and intergenic regions, were significant with both blood DNAm-to-CSF Aβ42/pTau181 association and brain DNAm-to-brain Aβ/tau association (Supplementary Tables 4–9).