GSTM5 and neurodegenerative disease: Among them, 3 DMRs were located in gene promoter regions and negatively associated with expression levels of the target genes at GSTM5, CAT, and CRISP2. GSTM5 belongs to the Glutathione S-Transferase family of genes, which encodes enzymes associated with oxidative stress in neurodegenerative diseases [59, 60].