TRAT1 and Alzheimer disease: Another noteworthy result is two overlapping DMRs significantly associated with CSF Aβ42, at chr6:30,130,819–30,131,284 in AD samples and chr6:30,130,819–30,131,362 in CN samples, both are located in the promoter of the TRIM15 gene, which encodes a member of the TRIM protein family involved in the ubiquitin system responsible for degrading misfolded protein aggregates and plays important roles in neurodegenerative diseases [107, 108].