Also, in CN samples, the most significant pathway is the calcium signaling pathway (P-value = 2.39 × 10−4, FDR = 9.09 × 10−3), consistent with the calcium hypothesis of AD, which posits that dysregulated neuronal calcium homeostasis induces impaired synaptic plasticity and defective neurotransmission, promotes accumulation of Aβ and tau proteins, and subsequently leads to neuronal apoptosis in the brain [98, 99]. This evidence concerns the gene MAPT and Alzheimer disease.