After correcting for multiple comparisons, at Sidak adjusted P-value less than 0.05, we observed blood DNAm at two DMRs, located on the HOXA5 and CHAD genes, were significantly associated with AD Braak stage in the London dataset, and overlapped with CSF pTau181 or Aβ42 associated DMRs in the ADNI dataset. This evidence concerns the gene HOXA5 and Alzheimer disease.