In CN samples, interestingly, among the most significant pathways enriched with significant CpGs is the KEGG pathway “Alzheimer’s disease”, which was curated based on recent AD literature and included genes that confer AD risks, such as APOE, PSENEN, MAPT, CALM3, MME, and others. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.