The maximum VAFs of somatic mutations in tumor tissues were illustrated in Fig. 3A. The top five mutated genes were EGFR (67.4% of patients, 29/43), TTN (30.2%, 13/43), TP53 (27.9%, 12/43), RBM10 (11.6%, 5/43), and RYR2 (11.6%, 5/43). Here, RYR2 is linked to neoplasm.