CD8A and familial pancreatic carcinoma: Notably, in comparison to the control group, 2-BP treatment significantly augmented an infiltration of CD8+T cells into Panc 02 tumors (Fig. 8F–I) as well as increased the expression of CCL5, CXCL9, and CXCL10, which are three important inflammatory cytokines accounting for the infiltration of CD8+T cells and reshaping the inflammatory TME in pancreatic cancer (Fig. 8J) [49].