As shown in Fig. 1A, after including the normal cases from GTEx project as controls, the expression level of 11 ZDHHCs (ZDHHC3/4/5/6/7/9/13/14/16/18/20) were significantly elevated in PAAD tissues compared with adjacent normal tissues (P < 0.05), and we did not obtain significant expression difference of other ZDHHCs. The gene discussed is ZDHHC3; the disease is pancreatic adenocarcinoma.