Pan-cancer results of cox regression analysis indicated that the ZDHHC3 expression significantly negatively correlated with OS in 6 types of cancer including PAAD, acute myeloid leukemia (LAML), liver hepatocellular carcinoma (LIHC), skin cutaneous melanoma (SKCM), and mesothelioma (MESO) (Additional file 1: Fig. S5). Here, ZDHHC3 is linked to pancreatic adenocarcinoma.