Overexpression of PD-L1 can almost completely reverse ZDHHC3 knockdown-induced inhibition of Panc 02 tumor growth and prolongation of mice survival time (Fig. 6J–L), suggesting that ZDHHC3 promotes pancreatic cancer progression probably via upregulation of PD-L1 expression by palmitoylation. Here, CD274 is linked to familial pancreatic carcinoma.