Strikingly, while the use of anti-PD-1 or anti-PD-L1 alone had almost no effect on Panc 02 tumor growth and mice survival time, the combination treatment of 2-BP and anti-PD-1 or anti-PD-L1 antibody markedly slowed tumor growth and prolonged the mice survival time (Fig. 9A–F). Here, CD274 is linked to neoplasm.