In the TCGA-PAAD cohort, analysis of the immunological status revealed that ZDHHC3 expression levels were negatively correlated with the majority of immunostimulatory factors, MHC molecules, chemokines, and their ligands, indicating that ZDHHC3 may play a role in the highly immunosuppressive TME of pancreatic cancer. Here, HLA-C is linked to familial pancreatic carcinoma.