The activities of the majority of the steps in the cancer-immunity cycle were suppressed in the high-ZDHHC3 group, including the release of cancer antigens presentation (Step 2), priming and activation (Step 3), and trafficking of immune cells to tumors (Step 4) (CD4+ T cell recruiting, CD8+ T cell recruiting, dendritic cells (DC) recruiting, macrophage recruiting, monocyte recruiting, NK cell recruiting, TH17 recruiting, and B cell recruiting,) (Fig. 4B). Here, CD8A is linked to cancer.