Consistently, knockdown of OTUD6B using short hairpin RNAs (shRNAs) resulted in a significant decrease in β‐TrCP protein but not β‐TrCP mRNA in KYSE30 and KYSE450 cells, two ESCC cell lines showing high endogenous OTUD6B expression level (Figure 1N,O). Here, OTUD6B is linked to esophageal squamous cell carcinoma.