BTRC and esophageal squamous cell carcinoma: Consistently, knockdown of OTUD6B using short hairpin RNAs (shRNAs) resulted in a significant decrease in β‐TrCP protein but not β‐TrCP mRNA in KYSE30 and KYSE450 cells, two ESCC cell lines showing high endogenous OTUD6B expression level (Figure 1N,O).