As an E3 ligase, β‐TrCP mediates the degradation of several substrate proteins through the UPS, including the EMT‐TF SNAIL that plays an importance role in regulating cancer stemness.[6, 15] In addition, the expression of SNAIL was significantly inhibited upon OTUD6B overexpression but increased when OTUD6B was knocked down, and these effects were mediated in a β‐TrCP‐dependent manner (Figure4A,B and Figure S4A,B, Supporting Information). The gene discussed is OTUD6B; the disease is cancer.