Since β‐TrCP is known to be heavily regulated by the ubiquitin‐proteasome system (UPS)[10] and it remains unclear whether there are DUBs directly regulating β‐TrCP protein stability, we determined to focus on identifying DUPs for β‐TrCP and examining their functions in ESCC progression. This evidence concerns the gene BTRC and esophageal squamous cell carcinoma.