SPP1 and idiopathic pulmonary fibrosis: Fibrosis promoting role of high osteopontin expression was shown in IPF patients.[32] Later, high SPP1‐expressing macrophages are identified as contributing to IPF.[45] Additionally, SPP1‐expressing myofibroblasts have also been emphasized as a fibrogenic myofibroblast population in IPF patients’ lungs.[39] In agreement with the previous observations, we also showed an increased expression of SPP1 in fibrotic lungs in human and mice (Figure 7D).