THEMIS and neoplasm: This effort identified a ten-gene, highly correlated, tumor-agnostic gene set inclusive of three genes from the antigen-presentation module (HLA-B, HLA-F and PSMB9) and seven from the cytotoxic immune module (CD2, CD3D, CD3E, CD3G, CXCR3, THEMIS and UBASH3A), which we have termed the ‘Pediatric Cytotoxicity and Antigen Presentation’ (PedCAP) gene set (Supplementary Table 4).