Reflective of previous reports in pediatric and adult cancers, most recurrently altered genes included the chromatin remodeling gene, ARID1B11,12 (n = 12), a histone methyltransferase, MLL2 (KMT2D)13,14 (n = 11) and the catalytic subunit of the DNA-dependent protein kinase, PRKDC15 (n = 9) (Extended Data Fig. 6a). Here, PRDM9 is linked to cancer.