TP53 and cancer: TP53 plays an important role in the regulation of cell response to stress and damage (Levine 2020); ERBB2 is a member of the epidermal growth factor receptor family, acting as tyrosine kinase receptors and it is considered a potent mediator of cell growth and cancer development (Wolfson et al. 2016); while PTEN is involved in many cellular functions including cell survival, proliferation, migration and adhesion (Yan et al. 2021).