The importance of critical interfaces between domains I, II and the 5.8S rRNA is further highlighted by the finding that key stabilizers of these sites include Rpl17 (RPL17 in humans) and Diamond-Blackfan anemia proteins Rpl26 (RPL26) and Rpl35 (RPL35) (Extended Data Fig. 9c–f)24,25. Here, RPL26 is linked to Blackfan-Diamond anemia.