In individuals with hypertension (Fig. 6b) we observed three patterns: (i) limbic tracts showed lower myelin in the seed structures but not targets, suggesting an anterior-posterior gradient of demyelination; (ii) fronto-parietal (SLF II and III), left fronto-occipital (IFOF) and projection tracts showed a generalised myelin decrease (i.e. in seed, tract and target); and (iii) parietal and occipital GM regions— targets of ILF, MLF and SLF I, seeds and targets of CC isthmus and splenium—showed reduced myelin in the absence of significant myelin differences in tracts. This evidence concerns the gene FOXK2 and hypertensive disorder.