Our data first showed that TAF15 knockdown led to a significant decrease in the phosphorylation levels of RAF1, MEK and ERK1/2, while total RAF1, MEK and ERK1/2 exhibited no significant change in GC cell lines (Fig. 5a–h) and xenograft tumours (Fig. 6g–j). The gene discussed is MAP2K7; the disease is gastric cancer.