For this end, we used 4 biotin-labeled anti-sense probes of AR mRNA to pull down AR mRNA complex and noticed IGFL2-AS1 was profoundly precipitated in pazopanib resistant ccRCC cells (Fig. 3C), suggesting According to RNA-RNA prediction sofware (http://rtools.cbrc.jp/cgi-bin/RNARNA/index.pl), IGFL2-AS1 interacts with the 5’-UTR region of AR mRNA (Supplementary Fig. 3C, D). Here, AR is linked to nonpapillary renal cell carcinoma.