It also mediates increased expression of inflammatory mediators such as NF-κB and Mcp-1, IL-6, and TNF-α that cause myocardial dysfunction and lead to the development of HF.35 Hyperglycemia promotes the increased expression of lncDACH1, which in turn promotes mitochondrial oxidative stress and apoptosis through increased ubiquitination-mediated degradation of NAD-dependent deacetylase sirtuin-3 (SIRT3), mitochondrial in mouse hearts, consequently aggravating DCM.36 Protein kinase C (PKC) is an effector in the G protein-coupled receptor system, and vascular SMC maintains vascular tone. Here, NFKB1 is linked to Hyperglycemia.