Chronic inflammation, abnormal lipid metabolism, and secondary autoimmunity are the main mechanisms.25 ApoB-specific CD4 T cells have been identified in humans and mice, and treg can be induced with ApoB peptides.26 Hsp60/65 is the target antigen of autoimmune T Cells.27 Hyperglycemic states can further promote autoimmune responses. The gene discussed is APOB; the disease is Autoimmunity.