In terms of compounds, for example, Glycyrrhizic Acid, and other compounds found in licorice can bind to Mpro, ACE2 and S proteins, respectively, which could inhibit COVID-19 replication and block virus binding sites12–14; in terms of targets, MAPKs, ILs and NF-kB can regulate the MAPK signaling pathway, the IL-17 signaling pathway and the NF-kB signaling pathway, exerting anti-inflammatory and immunomodulatory effects13. This evidence concerns the gene NFKB1 and COVID-19.