PMEL and neoplasm: The same results were demonstrated for geometric mean of IFN-γ- producing splenic/lymph node/intratumoral CD3+CD4+ T cells in the Lip-EPA + Lip-gp100 combination therapy group compared to other groups with significantly higher difference in tumor site (p < 0.0001) relative to spleen and lymp node tissues (p < 0.01) (Fig. 4E).