PMEL and neoplasm: In the intracellular cytokine analysis of T cell populations, it was found that the geometric mean of IFN-γ- producing CD3+CD8+ T cells in the spleen, lymph node, and tumor site in the mice received Lip-EPA + Lip-gp100 combination therapy was more than that of the other groups (p < 0.01 in spleen, p < 0.0001 in lumph node and tumor site; Fig. 4D).