The significant difference in the number of CD4 + CD25 + FOXP3 + Tcells in the lymph node and tumor tissues was found in the population of the EPA and gp100 monotherapy groups compared to the combination therapy groups EPA + gp100 and Lip-EPA + Lip-gp100 (p < 0.0001) (Fig. 4C). Here, CD4 is linked to neoplasm.