CD4 and melanoma: The CD4+ T cells, which includes two types of Th1 (induced by production of IFN-γ) and Th2 (responsible for B-cell antibody secretion, including interlukins) plays the major role of the immune response in melanoma, including the stimulation of CD8 + T cells activity by mediators such as IFN-γ, or IL-265,66.