CFD patients with left ventricular hypertrophy (cFD LVH +) were predominantly males (67%) and had significantly more Holter abnormalities like supraventricular/ventricular extrasystoles (SVES/VES), non-sustained ventricular tachycardia (nsVT), increased Lyso-Gb3 (21 ± 20 ng/ml vs. 9 ± 16 ng/ml), hs Troponin T (25 ± 24 ng/l vs. 5 ± 5 ng/l), NT-proBNP (526 ± 562 pg/ml vs. 80 ± 43 pg/ml) and higher prevalence of LGE (67% vs. 6%) compared to non-hypertrophied FD patients (cFD LVH-) (p < 0.05 for all, Table 3). This evidence concerns the gene NPPB and fleck corneal dystrophy.