Results of wound-healing and Transwell assays both showed that NTN1 overexpression rescued the inhibitory effect of sh-NSUN2 on the aggressive behavior of GC cells (Fig. 8g, h and Supplementary Fig. S7a, b, e, i, k), and NTN1 knockdown reversed the strengthened migration and invasion ability of GC cells induced by transfection of NSUN2 (Supplementary Fig. S7c, d, f, g, h, j, l). Here, NSUN2 is linked to gastric cancer.