In vivo mouse sciatic nerve model also demonstrated that overexpression of NTN1 to a great extent offset the inhibitory effect of sh-DIAPH2-AS1 on the growth of tumor (Fig. 5g), and NTN1 knockdown repressed the tumor growth accelerated by DIAPH2-AS1 overexpression (Fig. 5h). The gene discussed is NTN1; the disease is neoplasm.