Five carrier proteins have been used in licensed glycoconjugate vaccines, including Haemophilus protein D, tetanus toxoid, diphtheria toxoid, cross-reactive material 197 (CRM197, a non-toxic mutant form of diphtheria toxoid), and serogroup B meningococcus outer membrane protein complex (OMPC) [55]. Here, DHRS2 is linked to tetanus.